Figure 2.

Pedigree of rhesus macaques with known left ventricular hypertrophy. For simplicity, only macaques directly involved in the transmission of the disease phenotype to the probands are displayed; many more unaffected macaques, including close and distant relatives, have been omitted from the pedigree. Open squares and circles represent unaffected male and female macaques, respectively; shaded squares and circles represent affected male and female macaques (or probands), respectively. Dots indicate carriers, but their absence does not necessarily indicate that the subject is not a carrier. Generations are labeled in Roman numerals, whereas subjects within each generation are indicated in Arabic numerals.