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. Author manuscript; available in PMC: 2016 Apr 8.
Published in final edited form as: ACS Chem Biol. 2015 Jan 20;10(4):998–1009. doi: 10.1021/cb5007745

Figure 2.

Figure 2

Thiostrepton A and the analogs to be generated by site-directed mutagenesis of TsrA. a) Comparison of wild-type TsrA with the TsrA Ala4 variants encoded in the mutant fosmids. b) Structures of thiostrepton Ala4 analogs. The amino acid residue is abbreviated using a three-letter code. The analogs in grey are not produced. The observed analogs possessing no modification of the variant residue are highlighted in red, while the ones resulting from a modification of the variant residue are highlighted in blue.