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a) Thiostrepton A (Cyan) bound to the ribosome adapted from PDB 3CF5.(26) b) Thiostrepton Ala4Cys with the R configuration at the α-carbon of the 17th residue (magenta) modeled into the ribosome. c) Thiostrepton Ala4Cys with the S configuration at the α-carbon of the 17th residue (blue) modeled into the ribosome. Helices 43 and 44 of the 23S rRNA are colored in orange and the ribosomal protein L11 is shown in green.
