Table 3. Genotypic and allelic frequencies of the five studied SNPs: IL6 -174; IL12p40 +1188; IL4 +33; IL10 -3575; TGFb1+869 in the groups of symptomatic and asymptomatic patients .
| IL6 -174 G/C (rs1800795) | Symptomatic | Asymptomatic | Total | c2p | OR [95% CI] | c2pc | |
|---|---|---|---|---|---|---|---|
| Wild genotype | GG | 48 (46.15) | 21 (56.75) | 69 | 1.228 0.1339 | 0.6531 [0.30-1.39] | |
| Grouped genotypes | GC+CC | 56 (53.84) | 16 (43.24) | 72 | NC | ||
| Total | 104 | 37 | 141 | ||||
| Wild type alelle | G | 146 (70.19) | 57 (77.02) | 203 | 1.264 0.1304 | 0.7023 [0.37-1.30] | |
| Polymorphic alelle | C | 62 (29.80) | 17 (22.97) | 79 | NC | ||
| Total | 208 | 74 | 282 | ||||
| IL-12p40 A/C (rs3212227) | Symptomatic | Asymptomatic | Total | c 2 p | OR [95% CI] | c 2 pc | |
| Wild genotype | AA | 37 (35.57) | 17 (45.94) | 54 | 0.1242 0.1326 | 0.6497 [0.30-1.39] | |
| Grouped genotypes | AC+CC | 67 (64.42) | 20 (54.05) | 87 | NC | ||
| Total | 104 | 37 | 141 | ||||
| Wild type alelle | A | 129 (62.01) | 51 (68.91) | 180 | 1.125 0.1444 | 0.7364 [0.41-1.29] | |
| Polymorphic alelle | C | 79 (37.98) | 23 (31.08) | 102 | NC | ||
| Total | 208 | 74 | 282 | ||||
| IL-4 +33 C/T (rs2070874) | Symptomatic | Asymptomatic | Total | c 2 p | OR [95% CI] | c 2 pc | |
| Wild genotype | CC | 45 (43.26) | 14 (37.83) | 59 | 0.3308 0.2826 | 1.253 [0.58-2.70] | |
| Grouped genotypes | CT+TT | 59 (56.73) | 23 (62.16) | 82 | NC | ||
| Total | 104 | 37 | 141 | ||||
| Wild type alelle | C | 136 (65.38) | 41 (55.40) | 177 | 2.326 0.0636 | 1.520 [0.88-2.60] | |
| Polymorphic alelle | T | 72 (34.61) | 33 (44.59) | 105 | NC | ||
| Total | 208 | 74 | 282 | ||||
| IL10 -3575 T/A (rs1800890) | Symptomatic | Asymptomatic | Total | c 2 p | OR [95% CI] | c 2 pc | |
| Wild genotype | TT | 58 (55.76) | 28 (75.67) | 86 | 4.545 0.0165 | 0.4053 [0.17-0.94] | 0.3747 |
| Grouped genotypes | TA+AA | 46 (44.23) | 09 (24.32) | 55 | 0.0264 | ||
| Total | 104 | 37 | 141 | ||||
| Wild type alelle | T | 155 (74.51) | 64 (86.48) | 219 | 4.506 0.0169 | 0.4570 [0.21-0.95] | 3.842 |
| Polymorphic alelle | A | 53 (25.48) | 10 (13.51) | 63 | 0.0250 | ||
| Total | 208 | 74 | 282 | ||||
| TGFb1 +869 T/C (rs1800470) | Symptomatic | Asymptomatic | Total | c 2 p | OR [95% CI] | c 2 pc | |
| Wild genotype | TT | 44 (42.30) | 16 (43.24) | 60 | 0.00977 0.4606 | 0.9625 [0.45-2.05] | |
| Grouped genotypes | TC+CC | 60 (57.69) | 21 (56.75) | 81 | NC | ||
| Total | 104 | 37 | 141 | ||||
| Wild type alelle | T | 125 (60,09) | 45 (60,81) | 170 | 0.01164 0.4570 | 0.9705 [0.56-1.67] | |
| Polymorphic alelle | C | 83 (39,90) | 29 (39.18) | 112 | NC | ||
| Total | 208 | 74 | 282 | ||||
The c2 test with the Yates correction (pc) was used to determine differences between genotype and allele frequencies; OR - Odds Ratio, CI - confidence interval, pc= p value with Yates' correction. NC- not calculated.