Table 4. Genotypic and allelic frequencies of the five SNPs in the 141 recruited subjects according to parasitemia determined by the thick blood smear test .
Polymorphisms | Detectable Parasitemia N=69 | Non-Detectable Parasitemia N=72 | Total | c 2 p | OR [95% CI] | |
---|---|---|---|---|---|---|
IL6 -147 G/C | ||||||
Genotypic frequency | GG | 33 | 36 | 69 | 0.224 | NC |
GC | 33 | 32 | 65 | 0.893 | ||
CC | 3 | 4 | 7 | |||
Wild genotype | GG | 33 | 36 | 69 | 0.066 | 0.916 |
Grouped genotype | GC+CC | 36 | 36 | 72 | 0.796 | [0.47-1.77] |
Allelic frequency | G | 99 | 104 | 203 | 0.081 | 0.976 |
C | 39 | 40 | 79 | 0.928 | [0.58-1.64] | |
IL-12p40 A/C | ||||||
Genotypic frequency | AA | 23 | 31 | 54 | 1.689 | NC |
AC | 39 | 33 | 72 | 0.429 | ||
CC | 7 | 8 | 15 | |||
Wild genotype | AA | 23 | 31 | 54 | 1.409 | 0.661 |
Grouped genotype | AC+CC | 46 | 41 | 87 | 0.235 | [0.33-1.31] |
Allelic frequency | A | 85 | 95 | 180 | 0.585 | 0.827 |
C | 53 | 49 | 102 | 0.444 | [0.50-1.47] | |
IL-4 +33 C/T | ||||||
Genotypic frequency | CC | 27 | 32 | 59 | 0.556 | NC |
CT | 31 | 28 | 59 | 0.757 | ||
TT | 11 | 12 | 23 | |||
Wild genotype | CC | 27 | 32 | 59 | 0.408 | 0.803 |
Grouped genotype | CT+TT | 42 | 40 | 82 | 0.522 | [0.41-1.57] |
Allelic frequency | C | 85 | 92 | 177 | 0.158 | 0.906 |
T | 53 | 52 | 105 | 0.690 | [0.55-1.47] | |
IL10 -3575 T/A | ||||||
Genotypic frequency | TT | 39 | 47 | 86 | 1.372 | NC |
TA | 25 | 22 | 47 | 0.503 | ||
AA | 5 | 3 | ||||
Wild genotype | TT | 39 | 47 | 86 | 1.135 | 0.691 |
Grouped genotype | TA+AA | 30 | 25 | 55 | 0.286 | [0.35-1.36] |
Allelic frequency | T | 103 | 116 | 219 | 1.422 | 0.710 |
A | 35 | 28 | 63 | 0.233 | [0.40-1.24] | |
TGFβ1 +869 T/C | ||||||
Genotypic frequency | TT | 27 | 33 | 60 | 0.826 | NC |
TC | 25 | 25 | 50 | 0.661 | ||
CC | 17 | 14 | 31 | |||
Wild genotype | TT | 27 | 33 | 60 | 0.647 | 0.759 |
Grouped genotype | CT+CC | 42 | 39 | 81 | 0.421 | [0.38-1.48] |
Allelic frequency | T | 79 | 91 | 170 | 1.041 | 0.779 |
C | 59 | 53 | 112 | 0.307 | [0.48-1.25] |
Note: The c2test was used to determine statistical significance differences between genotypic and allelic frequencies; OR - Odds Ratio, CI - confidence interval; NC - not calculated.