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. 2015 Nov 5;9(5):317–323. doi: 10.1080/19336950.2015.1092836

Table 1.

PASS predicted activity score of piperine

Pa Pi Activities
0.906 0.009 Membrane integrity agonist
0.832 0.011 Neuroprotector
0.814 0.004 Neurotransmitter uptake inhibitor
0.740 0.004 Sigma receptor agonist
0.700 0.047 Depression
0.322 0.040 Sigma 1 receptor agonist
0.423 0.203 Nootropic
0.372 0.160 5 HT uptake stimulant
0.181 0.021 Nav1.8 sodium channel antagonist
0.281 0.132 GABA transporter 2 inhibitor
0.291 0.173 Dementia treatment
0.179 0.078 Neurodegenerative diseases treatment
0.069 0.009 GABA uptake inhibitor
0.079 0.030 Calcium channel T-type antagonist
0.213 0.201 Anticonvulsant
0.145 0.139 GABA C receptor agonist
0.104 0.099 Calcium channel antagonist
0.038 0.034 Kainate receptor antagonist