Table 2.

Effects of piperine on pentylenetetrazole induced seizures

Treatment	Dose (mg/kg)	Onset of myoclonic jerks (min)	Onset of tonic clonic convulsions (min)	% Mortality
Vehicle	10 ml	1.05 ± 0.21	1.79 ± 0.32	100
Diazepam	5	60 ± 0	60 ± 0	0
Piperine	5	4.77 ± 0.82	12.35 ± 3.04	100
	10	18.2 ± 1.35	47.6 ± 5.27	40
	20	7.992 ± 0.23	21.71 ± 0.95	100

Significant as compared to saline at ** p < 0.01, *** p < 0.001