Table 4.
Treatments | Onset of Convulsions (s) | % protection against seizures | % protection against mortality | |
---|---|---|---|---|
NMDA(0.31 µg/mouse) | Vehicle | 3.50 ± 0.35 | 0 | 0 |
PIP 20 mg/kg | 5.75 ± 1.25 | 0 | 0 | |
Picrotoxin(3.5 mg/kg) | Vehicle | 229.80 ± 10.20 | 0 | 0 |
PIP 20 mg/kg | 1134.60 ± 147.60 | 0 | 0 | |
Bicuculline(5 mg/kg) | Vehicle | 132.20 ± 17.40 | 0 | 0 |
PIP 20 mg/kg | 145.20 ± 4.20 | 0 | 0 | |
BAY K(37.5 µg/mice) | Vehicle | 6.92 ± 0.25 | 0 | 17 |
PIP 20 mg/kg | 1800.00 ± 0.00 | 100 | 100 | |
Strychnine(2 mg/kg) | Vehicle | 182.40 ± 7.80 | 0 | 0 |
PIP 20 mg/kg | 879.60 ± 25.80 | 0 | 0 |
Significant as compared to vehicle *** p < 0.001