Table 4.

Effect of piperine in different chemoconvulsant models

Treatments		Onset of Convulsions (s)	% protection against seizures	% protection against mortality
NMDA(0.31 µg/mouse)	Vehicle	3.50 ± 0.35	0	0
	PIP 20 mg/kg	5.75 ± 1.25	0	0
Picrotoxin(3.5 mg/kg)	Vehicle	229.80 ± 10.20	0	0
	PIP 20 mg/kg	1134.60 ± 147.60	0	0
Bicuculline(5 mg/kg)	Vehicle	132.20 ± 17.40	0	0
	PIP 20 mg/kg	145.20 ± 4.20	0	0
BAY K(37.5 µg/mice)	Vehicle	6.92 ± 0.25	0	17
	PIP 20 mg/kg	1800.00 ± 0.00	100	100
Strychnine(2 mg/kg)	Vehicle	182.40 ± 7.80	0	0
	PIP 20 mg/kg	879.60 ± 25.80	0	0

Significant as compared to vehicle *** p < 0.001