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. 2015 Sep 11;4(4):e1086062. doi: 10.1080/21624054.2015.1086062

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© 2015 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 3. — Model for why Dicer is so tightly regulated in the germline, and the embryo. During diakinesis (column 1), the oldest oocyte (−1) contains active MPK-1 and phosphorylated Dicer (green, inactive). As this oocyte exits diakinesis and matures (−1, column 2), MPK-1 is inactivated; Dicer is de-phosphorylated and presumably active. Active Dicer is then competent to generate small RNAs presumably in early embryos. These small RNAs may degrade maternal RNAs. Thus phosphorylation and dephosphorylation of Dicer appears to be necessary for the reprogramming of an oocyte to an embryo.