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. 2015 Sep 1;4(4):e1086869. doi: 10.1080/21624054.2015.1086869

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© 2015 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 2. — Conversion of TCF from a repressor to an activator via a conformational change. TCF acts as a repressor on classic TCF-sites (A). In Drosophila, binding to an atypical TCF-site induces a conformational change in TCF that converts TCF into an activator (B). We speculate that the Zic transcription factor REF-2 may induce a similar conformational change in the TCF transcription factor POP-1 converting it into an activator (C).