Table 2. Univariate analyses of patient and tumor characteristics for survival.
Event-free survival | Overall survival | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Variable | N used | N event | HR | 95% Lower | 95% Upper | p-value | N event | HR | 95% Lower | 95% Upper | p-value |
Time from 1st chemo to 3F8 | 170 | 75 | 0.906 | 0.839 | 0.978 | 0.012 | 46 | 0.938 | 0.856 | 1.029 | 0.179 |
Time from ASCT/last chemo to 3F8 | 170 | 75 | 0.726 | 0.553 | 0.954 | 0.022 | 46 | 0.889 | 0.666 | 1.188 | 0.426 |
ASCT (Y vs N) | 170 | 75 | 0.68 | 0.413 | 1.12 | 0.13 | 46 | 0.991 | 0.546 | 1.797 | 0.975 |
MYCN-amplified (Y vs N) | 162 | 74 | 0.747 | 0.473 | 1.179 | 0.21 | 46 | 0.681 | 0.380 | 1.219 | 0.196 |
Ultra-High-Risk (Y vs N) | 170 | 75 | 1.221 | 0.759 | 1.966 | 0.41 | 46 | 1.175 | 0.640 | 2.157 | 0.602 |
HAMA (Y vs N)* | 170 | 75 | 1.169 | 0.687 | 1.989 | 0.564 | 46 | 0.536 | 0.279 | 1.022 | 0.058 |
High-Dose 3F8 (Y vs N) | 170 | 75 | 1.507 | 0.791 | 2.871 | 0.212 | 46 | 2.220 | 0.902 | 5.467 | 0.083 |
Pre-MRD (Y vs N) | 170 | 75 | 1.009 | 0.617 | 1.648 | 0.972 | 46 | 1.269 | 0.696 | 2.313 | 0.436 |
Post-MRD (Y vs N)* | 165 | 72 | 4.997 | 2.894 | 8.627 | < 0.001 | 43 | 4.304 | 2.232 | 8.301 | < 0.001 |
FcGR2a | |||||||||||
HR vs HH | 170 | 75 | 0.679 | 0.401 | 1.149 | 0.149 | 46 | 0.702 | 0.362 | 1.362 | 0.295 |
RR vs HH | 170 | 75 | 0.865 | 0.469 | 1.594 | 0.642 | 46 | 0.748 | 0.336 | 1.666 | 0.477 |
FcGR3a | |||||||||||
VF vs FF | 170 | 75 | 0.654 | 0.347 | 1.234 | 0.19 | 46 | 0.794 | 0.339 | 1.86 | 0.596 |
VV vs FF | 170 | 75 | 0.646 | 0.332 | 1.258 | 0.199 | 46 | 0.862 | 0.357 | 2.08 | 0.741 |
KIR (Y vs N) | 170 | 75 | 0.864 | 0.528 | 1.411 | 0.558 | 46 | 0.953 | 0.501 | 1.81 | 0.882 |
KIR 2DL1 (Y vs N) | 170 | 75 | 0.973 | 0.617 | 1.534 | 0.907 | 46 | 1.37 | 0.766 | 2.45 | 0.288 |
KIR 2DL2 2DL3 (Y vs N) | 170 | 75 | 0.754 | 0.346 | 1.643 | 0.478 | 46 | 0.525 | 0.163 | 1.693 | 0.281 |
KIR 3DL1 (Y vs N) | 170 | 75 | 0.615 | 0.371 | 1.019 | 0.059 | 46 | 0.631 | 0.332 | 1.2 | 0.16 |
Trial (09–158/159 vs03–077) | 170 | 75 | 1.370 | 0.735 | 2.552 | 0.321 | 46 | 1.883 | 0.764 | 4.642 | 0.169 |
time-dependent variable