Table 3. Univariate and multivariate analyses of the influence of clinical parameters and voltage-dependent anion channel 1 (VDAC1) on survival of patients with cancer of the uterine cervix.

Clinicopathological and VDAC1 variablesa	Case number	5-year survival rate (%)	Hazard ratio	95% confidence interval	p value
Univariate analysis
Stage
I	82	83.6	1.00	Reference	0.25
others	45	70.7	1.47	0.75-2.88
Pathologic type
squamous cellcarcinoma	107	82.7	1.00	Reference	0.18
adenocarcinoma	21	60.7	1.72	0.78-3.79
Depth of stromal invasion
≤10 mm	49	98.0	1.00	Reference	<0.001
>10 mm	70	67.0	8.62	2.63-28.6
Tumor diameter
<4 cm	81	90.0	1.00	Reference	0.0068
>4 cm	36	60.9	2.56	1.26-5.21
Tumor grade
well	16	93.8	1.00	Reference	0.090
moderate or poor	94	78.4	4.78	0.65-35.71
Parametrial invasion
no invasion	95	85.9	1.00	Reference	0.003
invasion	32	59.4	2.65	1.36-5.18
Vaginal invasion
no invasion	103	80.2	1.00	Reference	0.44
invasion	25	75.8	1.35	0.63-2.88
Pelvic lymph node metastasis
negative	96	84.0	1.00	Reference	0.011
positive	30	62.2	2.38	1.19-4.76
VDAC1 immunoreactivity
negative	80	84.7	1.00	Reference	0.0036
positive	48	70.0	2.61	1.33-5.12
Multivariate analysis
VDAC1 immunoreactivity
negative	80	84.7	1.00	Reference	0.048
positive	48	70.0	2.22	1.01-4.90
Depth of stromal invasion
≤10 mm	49	98.0	1.00	Reference	0.002
>10 mm	70	67.0	6.79	2.04-22.6

Statistical analysis: Kaplan-Meier product limit method and univariate and multivariate Cox regression models.

^aSome clinicopathological data could not be collected from the patients with cervical cancer due to incomplete records of medical charts.