Skip to main content
. 2015 Dec 28;7(4):4326–4343. doi: 10.18632/oncotarget.6775

Figure 2. SLMP53-1 growth inhibitory effect in human wt p53- and mut p53R280K-expressing tumor cells is mediated by p53-dependent cell cycle arrest and/or apoptosis.

Figure 2

(A) GI50 value of SLMP53-1 in HCT116 cells, after 48 h treatment; values significantly different: **p < 0.01. (B) Cell cycle, (C) Apoptosis and (D) PARP cleavage after 24 h with 16 μM SLMP53-1 in HCT116 cells. (E) GI50 value for SLMP53-1 in MDA-MB-231 (mut p53R280K) and HuH-7 (mut p53Y220C) cells, after 48 h treatment. (F) Cell cycle, (G) Apoptosis and (H) PARP cleavage after 24 h with 16 μM SLMP53-1 in MDA-MB-231 cells. In A–C and E–G, data are mean ± SEM (n = 3–4). In A, B, C and G, values significantly different from DMSO only: *p < 0.05, **p < 0.01. In F, values are not significantly different from DMSO only: p > 0.05. In D and H immunoblots are representative of three independent experiments.