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. 2015 Dec 24;7(4):4399–4413. doi: 10.18632/oncotarget.6749

Figure 8. Sildenafil and DOX co-treatment reduces NF-κB activity in DU145 cells.

Figure 8

(A) NFκB activity in DU145 cells following 48 hr of treatment with DOX (0.5 μM) and/or Sild (10 μM). (B) Subcellular localization of p65 and p50 after 48 hr of treatment with DOX (0.5 μM) and/or Sild (10 μM). (C) Phosphorylation of IκB after 48 hr of treatment with DOX (0.5 μM) and/or Sild (10 μM). Densitometry analysis of the ratios of (D) pIκB to IκB, and (E) IκB to Actin. Abbreviations: doxorubicin – DOX; Sildenafil – Sild.