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. 2015 Dec 21;7(4):4442–4453. doi: 10.18632/oncotarget.6710

Figure 2. p130Cas expression prevents proteosome-independent ErbB2 degradation.

Figure 2

Left panel: BT474 silenced for or overexpressing p130Cas and relative controls were treated for 16 hours with MG132 (2 μM). Protein extracts were then blotted with antibodies against ErbB2, p130Cas and LC3. GAPDH was used as loading control. Right panel: Histograms show ErbB2 and LC3-II levels, normalized to GAPDH. Bars represent the means ± SEM of five independent experiments (ns: not significant; **p < 0.01; ***p < 0.001).