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. 2015 Dec 14;7(4):4522–4530. doi: 10.18632/oncotarget.6608

Figure 5. TIM3-Apt1 antagonizing aptamer enhances tumor-bearing mice in combination with PDL1 blockade.

Figure 5

A. CT26 tumor colon carcinoma was implanted subcutaneously in Balb/c mice; at day 2, 4, 7, 9 upon tumor implantation mice were treated intravenously with PDL1-blocking antibody (10F.9G2) and the TIM3-Apt1 antagonizing aptamer and tumor volume was monitored by caliber measurement. B. Tumor growth kinetics of mice treated with anti-PDL1 antibody and TIM3-Apt1 or anti-PDL1 antibody with Apt-control. C. Tumor size at day 31 upon tumor implantation of the mice treated with PDL1 antibody and TIM-Apt1 blockade or just with anti-PDL1 antibody and Apt-control (p=0.007) (n=5-6 mice per group).