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. 2015 Dec 15;7(4):4724–4734. doi: 10.18632/oncotarget.6619

Figure 5. GNB abundance is positively correlated with cell proliferation, tumor burden and outcome of therapy in human leukemia.

Figure 5

A–B. A positive correlation exists between cell proliferation (A) and GNB levels (B). Kcl-22M cells were treated with the mitogen FBS at various concentrations for indicated times and then collected for analyses of cell proliferation by MTT and GNBs by immunofluorescence staining. C–D. Depletion of GNBs with the small molecule inhibitor CGP57380 inhibited proliferation of leukemia cells with a dose-dependent manner. Kcl-22M cells were treated with the indicated concentrations of CGP57380 for 72 h and then analyzed for GNBs by immunofluorescent staining(C) and Cell viability by MTT (D). E. RNA-GNB abundance was positively associated with the malignant proliferative potential of the bone marrow (BM) in patients with leukemia. ***P < 0.001. F. A positive correlation between RNA-GNB levels and peripheral white blood cell count were observed in leukemia patients (R2=0.89). Note: Normal blood cell count is below 1 × 109L. G. RNA-GNB abundance was associated with response to chemotherapies. ***P < 0.001.