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. 2015 Dec 23;7(4):4841–4859. doi: 10.18632/oncotarget.6739

Figure 6. Cathepsin inhibitors are protective against cellular toxicity.

Figure 6

Viability and apoptosis/necroptosis rates of transfected cells following 48 h treatment with VP16 in the presence of CA-074-Me, pepstatin A, or E64D. Data represent percent viability and apoptosis/necroptosis rate when compared to DMSO-treated cells. (A) MTT assay indicated that three inhibitors increased the viability of leukemia cells in combination with Plent6.3-PIG7 and VP16 (*P < 0.05). (B) Annexin V staining also indicated that the three inhibitors protected leukemia cells from apoptosis and necroptosis (*P < 0.05).