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. 2015 Oct 5;7(4):5030–5041. doi: 10.18632/oncotarget.5456

Figure 1. Clinical, genetic and molecular characteristics of 107 young adult glioblastomas aging from 17 years to 35 years.

Figure 1

Mutation rates of BRAF, H3F3A and IDH1 were 15% (16/107), 18.7% (20/107) and 16.8% (18/107), respectively. No HIST1H3B mutation was detected. BRAF-V600E mutation was associated with CDKN2A deletion (p = 0.0002) and younger age (p = 0.013). H3F3A-K27M mutation was associated with midline tumor location (p < 0.00001). Positive PDGFRA expression co-occurred in 50% of H3F3A mutated tumors. IDH1-R132H mutation was associated with older age (p = 0.012). BRAF, IDH1, H3F3A-G34R/V mutations and EGFR amplification predominantly developed in hemispheric locations.