Table 3. Association of FGFR1 expression of clinic-pathological features and biomarker expression according to different luminal subtypes.
| Luminal A FGFR1 (%) | Luminal B FGFR1 (%) | |||||||
|---|---|---|---|---|---|---|---|---|
| Negative | Positive | Total | p-value | Negative | Positive | Total | p-value | |
| Clinic-pathological features | ||||||||
| Grade | 0.124 | 0.784 | ||||||
| 1 | 110 (92.4) | 9 (7.6) | 119 | 25 (78.1) | 7 (21.9) | 32 | ||
| 2 | 213 (89.5) | 25 (10.5) | 238 | 114 (77.0) | 34 (23.0) | 148 | ||
| 3 | 79 (85.9) | 13 (14.1) | 92 | 147 (76.2) | 46 (23.8) | 193 | ||
| Total | 402 (89.5) | 47 (10.5) | 449 | 286 (76.7) | 87 (23.3) | 373 | ||
| FF | 0.177 | 0.376 | ||||||
| Absence | 229 (90.9) | 30 (9.1) | 329 | 209 (78.0) | 59 (22.0) | 268 | ||
| Presence | 95 (86.4) | 15 (13.9) | 110 | 69 (73.4) | 25 (26.6) | 94 | ||
| Total | 394 (89.7) | 45 (10.3) | 439 | 278 (76.8) | 84 (23.2) | 362 | ||
| LVI | 0.010 | 0.972 | ||||||
| Absence | 309 (92.0) | 27 (8.0) | 336 | 172 (76.4) | 53 (23.6) | 225 | ||
| Presence | 78 (83.0) | 16 (17.0) | 94 | 95 (76.6) | 29 (23.4) | 124 | ||
| Total | 387 (90.0) | 43 (10.0) | 430 | 267 (76.5) | 82 (23.5) | 349 | ||
| pN | 0.023 | 0.279 | ||||||
| 0 | 225 (93.4) | 16 (6.6) | 241 | 138 (78.0) | 39 (22.0) | 177 | ||
| 1 | 117 (84.2) | 22 (15.8) | 139 | 76 (77.6) | 22 (22.4) | 98 | ||
| 2 | 38 (92.7) | 3 (7.3) | 41 | 42 (77.8) | 12 (22.2) | 54 | ||
| 3 | 14 (77.8) | 4 (22.2) | 19 | 27 (67.5) | 13 (32.5) | 40 | ||
| Total | 394 (89.7) | 45 (10.3) | 439 | 283 (76.7) | 86 (23.3) | 369 | ||
| pT | 0.003 | 0.330 | ||||||
| 1 | 207 (93.2) | 15 (6.8) | 222 | 102 (77.9) | 29 (22.1) | 131 | ||
| 2 | 174 (86.1) | 28 (13.9) | 202 | 156 (75.7) | 50 (24.3) | 206 | ||
| 3 | 10 (76.9) | 3 (23.1) | 13 | 17 (77.3) | 5 (22.7) | 22 | ||
| 4 | 3 (75.0) | 1 (25.0) | 4 | 3 (50.0) | 3 (50.0) | 6 | ||
| Total | 394 (89.3) | 47 (10.7) | 441 | 278 (76.2) | 87 (23.8) | 365 | ||
| Age | 0.282 | 0.720 | ||||||
| Mean | 56.7 | 54.5 | 56.4 | 52.3 | 52.0 | 52.2 | ||
| SD | 13.1 | 13.6 | 13.1 | 12.2 | 11.2 | 12.0 | ||
| Range | 30–97 | 28–91 | 22–85 | 31–89 | ||||
| Tumor size | 0.005 | 0.311 | ||||||
| Mean | 2.31 | 2.91 | 2.37 | 2.81 | 2.94 | 2.84 | ||
| SD | 1.16 | 1.54 | 1.22 | 1.78 | 1.61 | 1.73 | ||
| Range | 0.2–9.0 | 0.3–7.2 | 0.3–13.9 | 0.5–9.5 | ||||
| Biomarker | ||||||||
| ER | 0.490 | 0.137 | ||||||
| Neg | 17 (94.4) | 1 (5.6) | 18 | 36 (85.7) | 6 (14.3) | 42 | ||
| Pos | 386 (89.4) | 46 (10.6) | 432 | 251 (75.4) | 82 (24.6) | 333 | ||
| Total | 403 (89.6) | 47 (10.4) | 450 | 287 (76.5) | 88 (23.5) | 375 | ||
| P63 | 0.488 | 0.346 | ||||||
| Neg | 396 (89.6) | 46 (10.4) | 442 | 271 (77.0) | 81 (23.0) | 352 | ||
| Pos | 5 (83.3) | 1 (16.7) | 6 | 15 (68.2) | 7 (31.8) | 22 | ||
| Total | 401 (89.5) | 47 (10.5) | 448 | 286 (76.5) | 88 (23.5) | 374 | ||
| CK5/6 | 0.664 | 0.829 | ||||||
| Neg | 389 (89.6) | 45 (10.4) | 434 | 267 (76.3) | 83 (23.7) | 350 | ||
| Pos | 13 (86.7) | 2 (13.3) | 15 | 18 (78.3) | 5 (21.7) | 23 | ||
| Total | 402 (89.5) | 47 (10.5) | 449 | 285 (76.4) | 88 (23.6) | 373 | ||
| CK14 | 0.406 | 0.654 | ||||||
| Neg | 387 (89.8) | 44 (10.2) | 431 | 272 (76.4) | 84 (23.6) | 356 | ||
| Pos | 14 (82.4) | 3 (17.6) | 17 | 13 (81.3) | 3 (18.8) | 16 | ||
| Total | 401 (89.5) | 47 (10.5) | 448 | 285 (76.6) | 87 (23.4) | 372 | ||
| P-cadherin | 0.028 | 0.641 | ||||||
| Neg | 378 (90.4) | 40 (9.6) | 418 | 223 (76.9) | 67 (23.1) | 290 | ||
| Pos | 20 (76.9) | 6 (23.1) | 26 | 58 (74.7) | 20 (25.6) | 78 | ||
| Total | 398 (89.6) | 46 (10.4) | 444 | 281 (76.4) | 87 (23.6) | 368 | ||
| CG | 0.515 | 0.003 | ||||||
| Neg | 377 (90.0) | 42 (10.0) | 419 | 272 (77.9) | 77 (22.1) | 349 | ||
| Pos | 24 (85.7) | 4 (14.3) | 28 | 11 (50.0) | 11 (50.0) | 22 | ||
| Total | 401 (89.7) | 46 (10.3) | 447 | 283 (76.3) | 88 (23.7) | 371 | ||
| SYN | 0.009 | 0.030 | ||||||
| Neg | 347 (91.1) | 34 (8.9) | 383 | 250 (78.4) | 69 (21.6) | 319 | ||
| Pos | 54 (80.6) | 13 (19.4) | 67 | 35 (64.8) | 19 (35.2) | 54 | ||
| Total | 403 (89.6) | 47 (10.4) | 450 | 285 (76.4) | 88 (23.6) | 373 | ||
| Sox2 | 0.034 | 0.313 | ||||||
| Neg | 159 (88.8) | 20 (11.2) | 179 | 119 (75.8) | 38 (24.2) | 157 | ||
| Pos | 20 (74.1) | 7 (25.9) | 27 | 35 (68.6) | 16 (31.4) | 51 | ||
| Total | 179 (86.9) | 27 (13.1) | 206 | 154 (74.0) | 54 (26.0) | 208 | ||
Bold: statistically significant