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Consort diagram summarising enrolment, allocation, and follow-up. CT: computed tomography; PFTs: pulmonary function tests; BMI: body mass index; mMRC: modified Medical Research Council dyspnoea scale; 6MWD: 6-min walking distance; ELS: emphysematous lung sealant system. #: 47 patients were undergoing screening at the time of study termination.
