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A: Ligand concentrations (ng/g of brain tissue) in the cerebellum (grey bar) and striatum (black bar) of Sprague-Dawley rats at 5, 20, 40 and 60 min (n = 4 rats per time point) following intravenous administration of LY2459989 (3 μg/g); B: Dose-receptor occupancy relationship of LY2459989 at KOR, MOR and DOR.
