Table 1.

Regional V_T and BP_ND values of ¹¹C-LY2459989 under different conditions¹

Condition	Blocking Drug Dose (mg/kg)	Globus pallidus	Caudate	Putamen	Cingulate cortex	Insula	Frontal cortex	Temporal cortex	Thalamus	Cerebellum
		VT (mL·cm−3)
Baseline (n = 6)	–	12.7 ± 1.6	8.2 ± 1.4	8.1 ± 1.2	9.6 ± 2.0	8.4 ± 1.3	6.4 ± 1.0	6.1 ± 0.8	6.0 ± 0.9	4.0 ± 0.6
Naloxone (n = 2)	1.0	5.2 ± 0.6	4.9 ± 0.6	5.3 ± 0.8	4.9 ± 1.0	4.6 ± 0.7	4.4 ± 0.8	4.1 ± 0.5	4.8 ± 0.8	4.3 ± 0.6
LY2456302 (n = 1)	0.03	5.2	4.4	4.2	4.9	4.2	3.7	3.5	4.3	3.2
LY2456302 (n = 1)	0.3	4.2	4.2	4.4	4.2	3.8	3.7	3.7	4.2	3.8
LY2459989 (n = 2)	0.036	6.5 ± 2.1	5.3 ± 1.3	5.0 ± 0.8	5.6 ± 1.6	5.1 ± 1.3	4.5 ± 0.9	4.3 ± 0.6	4.9 ± 0.8	3.9 ± 0.1
11C–LY2795050 baseline (n = 4)2		5.2 ± 1.4	3.0 ± 1.4	4.2 ± 0.5	3.7 ± 1.4	3.4 ± 1.0	3.0 ± 1.1	2.8 ± 0.9	–	2.4 ± 0.6
		BPND
Baseline (n = 6)	–	2.18 ± 0.23	1.04 ± 0.13	1.03 ± 0.15	1.39 ± 0.25	1.08 ± 0.09	0.59 ± 0.09	0.51 ± 0.08	0.50 ± 0.11	–
Naloxone (n = 2)	1.0	0.20 ± 0.04	0.13 ± 0.02	0.23 ± 0.00	0.14 ± 0.07	0.07 ± 0.01	0.02 ± 0.03	–0.03 ± 0.02	0.10 ± 0.03	–
LY2456302 (n = 1)	0.03	0.64	0.37	0.32	0.53	0.31	0.15	0.09	0.34	–
LY2456302 (n = 1)	0.3	0.09	0.10	0.16	0.11	0.01	–0.02	–0.04	0.12	–
LY2459989 (n = 2)	0.036	0.67 ± 0.22	0.36 ± 0.25	0.30 ± 0.19	0.44 ± 0.30	0.31 ± 0.23	0.16 ± 0.17	0.10 ± 0.11	0.25 ± 0.20	–
11C–LY2795050 baseline (n = 4)2		0.97 ± 0.10	0.32 ± 0.26	0.66 ± 0.25	0.63 ± 0.21	0.39 ± 0.17	0.30 ± 0.16	0.15 ± 0.12	–	–

¹Mean ± SD, where applicable;

²Taken from reference (29).