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Change in LTE4 urine levels after low and standard oral graded aspirin challenge. 4a. After 20 mg aspirin challenge there was no significant change in LTE4 levels in either group. In AERD patients after 40 mg aspirin challenge, there was a significant increase in LTE4 levels (p=0.001). 4b. There was a significant increase in urinary LTE4 levels after standard graded aspirin challenge in AERD and in ATA patients (p<0.001 and p=0.02, respectively).
