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. Author manuscript; available in PMC: 2017 Apr 7.
Published in final edited form as: Cell. 2016 Mar 17;165(2):343–356. doi: 10.1016/j.cell.2016.02.023

Figure 1. Sustained inflammation induces fasting hyperglycemia.

Figure 1

(A) Fasting plasma glucose and insulin levels in mice given LPS for 7 days (7D-LPS) or mice receiving PBS as control (n=10/condition).

(B) Glucose tolerance test (GTT) in PBS or 7D-LPS treated mice (n=10/condition).

(C) Insulin tolerance test (ITT) in PBS or 7D-LPS treated mice (n=5/condition).

(D) Hyperinsulinemic-euglycemic clamp was performed on PBS or 7D-LPS treated mice and endogenous glucose production and glucose uptake were measured (n=4-7/condition).

(E) Insulin stimulated phosphorylated-AKT on serine 473 (pS473-AKT) was evaluated in tissues from overnight fasted PBS or 7D-LPS mice. Bar plots represent densitometry analysis of pS473-AKT/AKT (n=3-4/condition). Data is presented as mean ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 by Student’s T-Test. # p < 0.05, ## p < 0.01 by two-way analysis of variance (2-ANOVA). See also Figure S1.