Skip to main content
. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Neuroscientist. 2015 Oct 8;22(5):447–463. doi: 10.1177/1073858415608147

Figure 4.

Figure 4

Hypothesized role of chromatin remodeling ACF complex in NAc in stress susceptibility. Chronic social defeat stress CSDS, via increased burst firing of VTA neurons and BDNF release, induces ACF1 expression in NAc. The resulting upregulation of ACF complex activity, possibly through changes in TSS (transcription start site) nucleosome positioning, represses a set of genes in NAc, the reduced expression of which contributes to susceptibility. Blurry nucleosomes in the right figure represent weakly positioned or delocalized nucleosomes at TSSs. From Sun and others (2015) (permission not required).