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. Author manuscript; available in PMC: 2017 Jul 15.
Published in final edited form as: Biol Psychiatry. 2015 Oct 8;80(2):140–148. doi: 10.1016/j.biopsych.2015.09.018

Figure 1.

Figure 1

Forebrain specific knockout of Mef2c leads to increased spine density. (A) Mef2c mRNA expression in frontal cortex (FC), striatum (STR), hippocampus (HC), and cerebellum (CBL) of conditional Mef2c knockout (KO) mice generated using the CaMKII-Cre93 driver line and littermate control (CTL) mice. Levels of Mef2c mRNA were normalized to Gapdh relative to CTL mice. (B) Spine density of granular neurons in the dentate gyrus as assessed by Golgi staining (n=5 mice for both CTL and KO). (C) Representative images of granular neurons from the dentate gyrus (*p < 0.05).