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. Author manuscript; available in PMC: 2017 Jul 15.
Published in final edited form as: Biol Psychiatry. 2015 Oct 8;80(2):140–148. doi: 10.1016/j.biopsych.2015.09.018

Figure 2.

Figure 2

Mef2c KO mice are hyperactive and have impaired motor coordination. (A) Locomotor activity was measured over 2 hrs and the number of beam breaks is presented in 5 min blocks of time. Inset, the total number of beam breaks for the 2 hr time period (CTL, n=9; KO, n=7). (B) Motor coordination was assessed in the rotarod test. Mice performed 4 trials per day for 2 days and the latency to fall from the accelerating rotarod was measured (CTL, n=9; KO, n=8). (C) The severity of hindlimb clasping was scored in mice at 5 months of age (CTL, n=5; KO, n=5) (*p < 0.05).