Table 2.
Age adjusted associations between participant characteristics and the distribution of T-cell phenotypes among 85 participants in the Detroit Neighborhood Health Study.
| β (95% confidence intervals) | |||||||
|---|---|---|---|---|---|---|---|
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| |||||||
| CD4 | CD8 | ||||||
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| CD4:CD8 ratioa | E:N ratioa | %KLRG1b | %CD57b | E:N ratioa | %KLRG1b | %CD57b | |
| Each 10-year increase in age | 0.00 (−0.05, 0.06) | 0.56 (0.16, 0.95)* | 0.14 (0.03, 0.25)* | 0.17 (0.05, 0.28)* | 0.55 (0.33, 0.77)* | 0.21 (0.12, 0.31)* | 0.20 (0.08, 0.31)* |
| Females versus males | 0.15 (−0.04, 0.34) | 0.23 (−1.13, 1.59) | −0.12 (−0.50, 0.26) | 0.01 (−0.39, 0.42) | −0.74 (−1.48, −0.002)* | −0.22 (−0.56, 0.12) | −0.32 (−0.70, 0.07) |
| Black/African American versus other | −0.11 (−0.35, 0.12) | 0.81 (−0.85, 2.46) | 0.09 (−0.38, 0.56) | 0.44 (−0.06, 0.94) | 0.22 (−0.71,1.15) | 0.23 (−0.11, 0.56) | 0.27 (−0.20, 0.75) |
| ≤High school education versus >High school | −0.02 (−0.21, 0.16) | −0.49 (−1.78, 0.79) | −0.19 (−0.56, 0.17) | −0.16 (−0.54, 0.22) | 0.27 (−0.45, 0.98) | 0.13 (−0.20, 0.46) | 0.14 (−0.23, 0.51) |
| Medication use versus no medication usec | 0.05 (−0.15, 0.25) | −0.53 (−1.94, 0.87) | −0.32 (−0.77, 0.13) | −0.20 (−0.62, 0.22) | −0.36 (−1.16, 0.45) | −0.08 (−0.44, 0.29) | −0.13 (−0.54, 0.28) |
| Cigarette use versus no cigarette use | −0.08 (−0.26, 0.11) | 0.72 (−0.59, 2.03) | 0.13 (−0.25, 0.50) | 0.13 (−0.26, 0.52) | 0.20 (−0.54, 0.93) | 0.00 (−0.34, 0.34) | 0.07 (−0.31, 0.45) |
| Lifetime PTSD versus no lifetime PTSD | −0.27 (−0.48, −0.05)* | 1.55 (0.04, 3.05)* | 0.56 (0.00,1.13)* | 0.65 (0.03,1.27)* | 0.92 (0.08, 1.76)* | 0.34 (−0.05, 0.73) | 0.55 (0.06, 1.05)* |
| Past-year PTSD versus no past-year PTSD | −0.36 (−0.60, −0.13)* | 1.91 (0.23,3.60)* | 0.77 (0.16,1.38)* | 0.47 (−0.01, 0.96) | 1.39 (0.47, 2.31)* | 0.55 (0.12, 0.98)* | 0.67 (0.20, 1.15)* |
Abbreviations: PTSD, posttraumatic stress disorder; E:N ratio, ratio of end-stage non-proliferative effector cells (E; CCR7-CD45RA+CD27-CD28-orTEMRA) to naïve T-cells (N; CCR7+CD45RA+CD27+CD28+).
*
p value <0.05.
a
Estimates are in log ratio units.
b
Estimates are in log odds.
c
Medications included antimicrobial agents, cardiovascular-renal drugs, central nervous system medications, metabolic and nutrient agents, hormones and agents affecting hormonal mechanisms, immunologic agents, oncolytics, and drugs used for relief of pain. 3 individuals were missing data on medication use.