Table 1.

Inhibitory Activity and Selectivity of Flavone Derivatives toward P450 1A2^a

Compound	Short Name	Structure	Ki (μM)			Selective Index (SI)
			1A1	1A2	1B1	1A1/1A2	1B1/1A2
Furafylline			>200	68.0 ±13.2	>200	>2.9	>2.9
α-Naphtho flavone	αNF		0.045 ±0.010	0.020 ±0.005	0.016 ±0.002	2.3	0.8
2	78PF		0.27 ±0.02	0.058 ±0.018	0.053 ±0.032	4.7	0.9
3	78FF		0.43 ±0.19	0.030 ±0.002	0.18 ±0.05	14	6.0
5	5H78PF		0.11 ±0.02	0.014 ±0.004	0.0056 ±0.0020	7.9	0.4
8	5H78FF		0.47 ±0.12	0.044 ±0.023	0.10 ±0.06	11	2.3
11	78PyF		0.040 ±0.008	0.076 ±0.011	0.12 ±0.02	0.5	1.8
12	78DOF		1.23 ±0.22	0.090 ±0.034	0.48 ±0.21	14	5.3

^aThe K_i values are represented as the mean ± SD μM of three independent experiments.