Table 2.

Cytotoxicity of 1,5-Diheteroarylpenta-1,4-dien-3-ones

compd	inhibitory rate (%)
	PC-3a		DU145b		LNCaPc		HeLad
	10 μM	1 μM	10 μM	1 μM	10 μM	1 μM	10 μM	1 μM
curcumin	55.07	2.45	58.49	7.25	65.45	28.78	50.30	13.75
6	94.34	76.97	84.97	45.75	80.90	53.63	95.13	92.70
7	97.39	84.35	86.93	50.02	78.17	47.27	97.56	94.59
8	93.91	91.30	84.97	65.70	80.90	77.26	96.48	97.83
9	90.87	91.30	83.66	63.74	91.80	50.90	96.75	97.02
10	84.59	87.50	93.39	79.25	72.49	41.66	97.13	96.69
11	92.17	85.22	88.56	35.93	85.44	52.72	98.91	89.73
12	82.83	92.42	89.08	91.70	85.70	77.13	97.25	95.73
13	93.94	89.90	87.77	83.41	88.56	61.42	94.81	97.25
14	90.91	92.93	94.32	84.28	88.56	67.13	95.73	96.03
15	85.52	71.98	90.00	79.55	83.86	51.60	96.34	96.95
16	59.40	0.00	47.18	19.34	58.32	18.52	84.08	18.27
17	27.15	0.00	0.01	0.00	38.70	6.45	20.72	0.00
18	70.76	0.00	84.25	31.48	52.77	9.26	92.69	32.36
19	86.92	80.85	87.27	67.29	83.86	61.28	99.08	96.34
20	87.39	9.37	85.91	0.01	41.93	25.80	97.56	16.15
21	94.55	50.03	85.96	27.25	50.72	31.88	99.18	69.12
22	89.60	69.82	85.11	54.07	68.11	59.07	97.83	68.30
23	89.60	19.33	90.21	23.85	46.37	14.49	98.64	22.75
24	89.47	84.22	90.32	54.86	77.14	64.39	93.67	76.59
25	91.92	13.16	82.97	21.42	64.99	45.71	89.63	14.63
26	84.85	73.75	93.45	69.88	84.99	77.85	96.64	97.25
27	86.71	8.05	77.66	4.76	53.70	15.74	97.65	26.62
28	91.59	37.89	75.47	0.01	68.80	22.58	97.86	33.82
29	87.77	31.97	89.74	31.85	78.69	29.62	95.04	40.19
30	81.92	57.48	90.11	42.13	78.69	26.85	98.17	50.37
31	83.79	0.90	86.53	23.48	66.95	9.61	96.52	21.19
32	60.96	4.20	48.42	4.03	74.10	48.21	96.52	79.75
33	1.64	0.00	6.22	6.22	14.28	11.61	21.51	6.64
34	25.73	14.40	35.23	13.46	23.43	34.37	48.97	22.91
35	69.81	6.29	46.80	18.16	69.52	21.87	96.18	21.34
36	78.84	81.09	90.83	55.32	67.96	45.31	97.97	95.50
37	86.14	84.66	81.95	64.60	91.19	74.71	98.87	92.09
38	85.15	89.60	79.87	67.37	79.11	73.11	98.87	95.48
39	83.17	88.62	87.15	64.95	85.70	68.12	97.74	97.17
40	81.69	89.60	89.58	60.78	90.09	32.96	97.45	98.02
41	82.82	62.00	91.13	79.85	78.21	60.46	96.99	96.29
42	88.12	72.79	86.11	36.46	74.71	42.07	97.45	90.40
43	83.79	79.29	84.82	92.26	88.27	62.49	97.53	96.63
44	84.19	88.46	85.77	84.19	79.42	59.26	89.25	93.12
45	84.69	91.44	87.11	89.11	77.33	70.30	97.08	95.28
46	87.61	69.67	88.54	75.00	67.32	59.25	94.17	90.66
47	91.02	71.97	81.43	79.60	70.55	45.95	97.34	90.66
48	83.34	58.49	80.24	79.40	72.97	54.00	96.64	96.29

^aHuman androgen-insensitive prostate cancer cell line.

^bHuman androgen-insensitive prostate cancer cell line.

^cHuman androgen-sensitive prostate cancer cell line.

^dHuman aggressive cervical cancer cell line.