Table 4.
compd | IC50(curcumin)/IC50(compd)a
|
|||||
---|---|---|---|---|---|---|
PC-3b
|
DU145,c WST-1 | LNCaP,d WST-1 | HeLae
|
|||
WST-1 | TB | WST-1 | TB | |||
curcumin | 1 | 1 | 1 | 1 | 1 | 1 |
6 | 24 | 29 | 23 | 23 | ||
7 | 17 | 40 | 17 | 30 | ||
8 | 37 | 71 | 28 | 53 | ||
9 | 36 | 48 | 23 | 35 | ||
10 | 28 | 31 | 12 | 19 | ||
12 | 82 | 90 | 57 | 64 | 75 | |
13 | 37 | 42 | 24 | 34 | 42 | |
14 | 36 | 37 | 24 | 30 | 46 | |
15 | 42 | 49 | 35 | 37 | ||
19 | 50 | 58 | 44 | 87 | 51 | |
22 | 30 | 27 | 30 | 18 | ||
24 | 36 | 23 | 23 | 26 | 11 | |
26 | 54 | 56 | 59 | 61 | 43 | |
30 | 35 | 17 | 20 | 17 | ||
32 | 54 | 30 | 40 | 33 | 29 | 22 |
36 | 121 | 32 | 77 | 50 | 87 | 24 |
37 | 49 | 63 | 36 | 53 | ||
38 | 75 | 66 | 26 | 71 | ||
39 | 64 | 51 | 24 | 61 | ||
40 | 69 | 38 | 16 | 38 | ||
41 | 40 | 14 | 12 | 21 | ||
43 | 111 | 90 | 50 | 30 | 76 | 75 |
44 | 116 | 58 | 61 | 36 | 87 | 95 |
45 | 75 | 53 | 32 | 17 | 53 | 45 |
46 | 85 | 18 | 30 | 19 | 45 | 15 |
47 | 98 | 13 | 32 | 25 | 67 | 11 |
48 | 32 | 15 | 22 | 13 |
The relative potency of curcumin mimics obtained by dividing the IC50 value of curcumin by that of each curcumin mimic.
Human androgen-insensitive prostate cancer cell line.
Human androgen-insensitive prostate cancer cell line.
Human androgen-sensitive prostate cancer cell line.
Human aggressive cervical cancer cell line.