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. Author manuscript; available in PMC: 2016 Apr 8.
Published in final edited form as: J Med Chem. 2015 May 22;58(11):4713–4726. doi: 10.1021/acs.jmedchem.5b00470

Table 4.

Relative Potency of Curcumin Mimics

compd IC50(curcumin)/IC50(compd)a
PC-3b
DU145,c WST-1 LNCaP,d WST-1 HeLae
WST-1 TB WST-1 TB
curcumin     1   1   1   1   1   1
6   24 29 23 23
7   17 40 17 30
8   37 71 28 53
9   36 48 23 35
10   28 31 12 19
12   82 90 57 64 75
13   37 42 24 34 42
14   36 37 24 30 46
15   42 49 35 37
19   50 58 44 87 51
22   30 27 30 18
24   36 23 23 26 11
26   54 56 59 61 43
30   35 17 20 17
32   54 30 40 33 29 22
36 121 32 77 50 87 24
37   49 63 36 53
38   75 66 26 71
39   64 51 24 61
40   69 38 16 38
41   40 14 12 21
43 111 90 50 30 76 75
44 116 58 61 36 87 95
45   75 53 32 17 53 45
46   85 18 30 19 45 15
47   98 13 32 25 67 11
48   32 15 22 13
a

The relative potency of curcumin mimics obtained by dividing the IC50 value of curcumin by that of each curcumin mimic.

b

Human androgen-insensitive prostate cancer cell line.

c

Human androgen-insensitive prostate cancer cell line.

d

Human androgen-sensitive prostate cancer cell line.

e

Human aggressive cervical cancer cell line.