Figure 1. Association between number of comorbidities and the likelihood of disease-modifying therapy (DMT) initiation.

^aResults were obtained from Cox proportional hazards models with comorbidity count at index date as a time-dependent variable (i.e., count × time). ^bResults were obtained from Cox proportional hazard models with comorbidity count during follow up as a time-varying variable. Models were adjusted for age, sex, year of index date, and socioeconomic status. CI = confidence interval.