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. Author manuscript; available in PMC: 2016 Apr 9.
Published in final edited form as: Nat Rev Drug Discov. 2015 Mar 20;14(4):248–260. doi: 10.1038/nrd4539

Figure 3. In vivo engineering of bone marrow.

Figure 3

A bone marrow-on-a-chip model leveraged in vivo tissue engineering approaches to generate fully functional engineered bone marrow (eBM) for incorporation and perfusion culture in a microfluidic device. The eBM had a physiological structure and was used in an organ-on-a-chip system to study depletion and pharmacological protection of haematopoietic stem and progenitor cell populations exposed to γ-radiation. The red and green channels are medium perfusion channels used to maintain the eBM in the central chamber. PDMS, poly(dimethylsiloxane).