Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Apr 1;30(7):751–771. doi: 10.1101/gad.277137.115

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016 Brewer et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

Figure 1. — Fgfr alternative splicing facilitates interactions between epithelial and mesenchymal tissues. (A) Alternative splicing of exons 8 and 9 generates b and c isoforms of Fgfr1–3, while exon 10 encodes an invariant transmembrane domain. (B,C) Fgf ligands expressed in epithelium engage Fgfrc isoforms in the adjacent mesenchyme (B), while ligands expressed in the mesenchyme activate Fgfrb isoforms in the epithelium (C). Paracrine signaling also depends on the heparan sulfate proteoglycan (HSPG) coreceptor. (D) Endocrine Fgf ligands use Klotho coreceptors rather than HSPGs. (Ex) exon; (TK) tyrosine kinase. The exon, Fgfr isoform, and cell type specificity are color coded, with blue and green representing epithelium and mesenchyme, respectively.