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Fgfrs use diverse mechanisms of signaling. Fgfr1 functions through multiple effectors that converge on downstream Erk1/2 signaling in multiple contexts, including axial elongation and development of the pharyngeal arches. In contrast, Fgfr3 uses differential signaling during distinct cellular responses in growth plate chondrocytes. Here, Stat1 is engaged to limit chondrocyte proliferation, and Erk1/2 is subsequently used to inhibit hypertrophic differentiation.
