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. 2016 Apr 1;30(7):798–811. doi: 10.1101/gad.274951.115

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© 2016 Li et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 4. — Active SRC prominently cooperates with YAP1 in the malignant transformation of primary keratinocytes. (A) Growth curve analysis of keratinocytes stably transduced with empty vectors (Ctrl), wild-type hYAP1 (YAP), 2SA YAP1 (2SA YAP), and CA-SRC. Values represent mean ± SD. n = 3. Student's t-test. (A′) Western blot (WB) analyses of total proteins from the cells in A using the indicated antibodies. (B) Orthotopic allograft tumor formation assays in NOD-SCID mice using primary keratinocytes stably transduced with the expression constructs described in A. (B′) Quantitation of tumor size differences in B. Data represent mean ± SE. P-values were calculated by unpaired t-test.