Table 3.

Association between CpG sites and former smokers compared with never smokers, time since smoking cessation and cumulative smoking exposure in pack-years

CpG site	Gene	Former vs never smokers		Cessation time		Pack-years
		β (SE)	p value	βa (SE)	p value	βa (SE)	p value
cg23161492	ANPEP	−0.007 (0.006)	0.24	0.014 (0.003)	2.6 × 10−6	−0.007 (0.002)	2.8 × 10−3
cg26963277	KCNQ1	−0.006 (0.003)	0.05	0.006 (0.002)	2.1 × 10−4	−0.006 (0.002)	9.0 × 10−4
cg03450842	ZMIZ1	−0.005 (0.002)	0.06	0.002 (0.001)	0.20	−0.003 (0.001)	1.6 × 10−3
cg01744331	KCNQ1	−0.003 (0.002)	0.21	0.005 (0.001)	5.1 × 10−5	−0.004 (0.001)	1.1 × 10−4
cg16556677	KCNQ1	−0.007 (0.003)	7.1 × 10−3	0.005 (0.001)	1.2 × 10−3	−0.003 (0.001)	0.05

Adjusted for age, sex, BMI, white blood cell counts and batch effects. Bonferroni corrected

^aβ represents change in methylation per 10 years since smoking cessation and per 10 pack-years.