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. 2016 Feb 21;62(9):1092–1099. doi: 10.1093/cid/ciw085

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© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, contact journals.permissions@oup.com.

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Figure 1. — Forest plot of relative efficacy against laboratory-confirmed influenza illness caused by any strain. Illness corresponds to protocol-defined influenza-like illness in year 2. Vaccine efficacy (VE) is the percent efficacy of the different vaccination patterns relative to the year 1 (Y1) standard-dose inactivated influenza vaccine (IIV-SD), year 2 (Y2) IIV-SD vaccination pattern. Vaccination patterns are based on vaccine assigned at randomization in Y2, and vaccine actually received in Y1. The plot on the right depicts the relative VE estimates for the vaccination patterns; horizontal lines represent the 95% confidence intervals (CIs), and solid squares represent the point estimates. All estimates to the right of the null value of 0 favor the corresponding pattern over the referent. CIs that do not intersect with the null value are statistically significant. Abbreviation: IIV-HD, high-dose inactivated influenza vaccine.