Table 1.
Effect of A. javanica total ethanolic extract on CCl4-induced hepatotoxicity-related parameters in rats
| Treatment group | SGOT | SGPT (U/l) | ALP (U/l) | GGT (U/l) | Bilirubin (mg/dl) |
|---|---|---|---|---|---|
| Control | 107.45±5.31 | 28.83±2.20 | 321.66±13.88 | 4.06±0.32 | 0.54±0.01 |
| CCl4 | 294.83±8.33***a | 230.83±9.62***a | 515.16±13.70***a | 12.85±0.98***a | 2.16±0.08***a |
| A. javanica (100 mg) + CCl4 | 279.33±7.81b | 174.33±6.13***b | 437.00±8.66***b | 10.28±0.43*b | 1.81±0.05**b |
| A. javanica (200 mg) + CCl4 | 246.00±3.74***b | 140.16±4.04***b | 412.66±8.84***b | 6.86±0.33***b | 1.54±0.02***b |
| Silymarin (10 mg) + CCl4 | 136.66±6.00***b | 85.66±4.31***b | 396.33±7.62***b | 5.58±0.28***b | 1.06±0.06***b |
All values represent mean±SEM
*
P<0.05
**
P<0.01
***
P<0.001; ANOVA, followed by Dunnet's multiple comparison test
a
As compared with normal group.
b
As compared with CCl4-only group.