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. Author manuscript; available in PMC: 2017 Apr 7.
Published in final edited form as: Mol Cell. 2016 Apr 7;62(1):79–91. doi: 10.1016/j.molcel.2016.03.001

Figure 2. Liver-specific enhancers retain MNase-accessible nucleosomes genome-wide.

Figure 2

(A) Averaged profiles of low- and high-MNase-seq signal enrichments at, liver-specific enhancers ubiquitous enhancers, and active promoters. p-values by Wilcoxon rank-sum test at central 200 bp of enhancers and at upstream 200 bp from active TSS (pink box area). (B, E) Heatmaps of MNase-seqs and FoxA2 ChIP-exo at liver-specific enhancers, ubiquitous enhancers, and active promoters, rank ordered by low-MNase-seq read density. (C) Box and whisker plots show H3 and H2B ChIP-seq signal enrichment at central 200 bp of liver-specific and ubiquitous enhancers and at upstream 200 bp from active TSS. p-value by Wilcoxon rank sum test. (D) Gene expression levels of target genes of liver-specific and ubiquitous enhancers, based on predicted enhancer-promoter pairs (Shen et al., 2012). (See also Figure S2)