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. Author manuscript; available in PMC: 2017 Apr 7.
Published in final edited form as: Mol Cell. 2016 Apr 7;62(1):79–91. doi: 10.1016/j.molcel.2016.03.001

Figure 3. Pioneer factor FoxA2 and liver TFs are co-localized at accessible nucleosomes in liver-specific enhancers.

Figure 3

(A) FoxA2 ChIP-exo tag 5’ end distribution centered by de novo FoxA motif midpoint and sorted by FoxA2 occupancy level. (B) Averaged profiles of low- and high-MNase-seq at TSS-distal FoxA2 binding sites, and (C) at CTCF binding sites overlapping with H3K27ac peaks. (D. E) Heatmaps of MNase-seqs, and FoxA2 ChIP-exo, C/EBβ and HNF4α ChIP-seq at MNase-accessible nucleosomes in liver-specific enhancers, rank ordered by low-MNase-seq read density. (F) Profiles of de novo motifs enrichment relative to midpoint of accessible nucleosome in enhancers. (G) Histogram of FoxA2 ChIP-exo binding locations relative to midpoint of accessible nucleosomes. The midpoint approximating the position of the respective nucleosome dyad axis. (See also Figure S3)