A. Hypertensive SRC (fulfills both A1 and A2)

1. New onset hypertension, defined as any of the following:

a) Systolic blood pressure ≥ 140 mgHg b) Diastolic blood pressure ≥ 90 mgHg c) Rise in systolic blood pressure ≥ 30 mmHg d) Rise in diastolic blood pressure ≥ 20 mmHg

AND

2. One (1) of the following five (5) features:

a) Increase in serum creatinine by 50+% over baseline OR serum creatinine ≥120% of upper limit of normal for local laboratory b) Proteinuria ≥2+ by dipstick c) Hematuria ≥2+ by dipstick or ≥10 RBCs/HPF d) Thrombocytopenia: <100,000 platelets/mm3 e) Hemolysis defined as anemia not due to other causes and either of the following: (1) Schistocytes or other RBC fragments seen on blood smear (2) increased reticulocyte count

B. Normotensive SRC (fulfills both B1 and B2)

1. Increase in serum creatinine >50% over baseline OR serum creatinine ≥120% of upper limit of normal for local laboratory

AND

2. One (1) of the following five (5) features:

a) Proteinuria ≥2+ by dipstick b) Hematuria ≥2+ by dipstick or ≥10 RBCs/HPF c) Thrombocytopenia: <100,000/mm3 d) Hemolysis defined as anemia not due to other causes and either of the following: (1) Schistocytes or other RBC fragments seen on blood smear (2) Increased reticulocyte count e) Renal biopsy findings consistent with scleroderma renal crisis (microangiopathy)