. 2016 Apr 9;11:35. doi: 10.1186/s13000-016-0484-4

Table 3.

Univariate Cox regression analysis

PHH3 quantification type with index categorized by median	Progression-free survival
PHH3 quantification type with index categorized by median	HR	95 % CI	P
Manual count & outline, hot spot, 0 vs. ≥ 1.0	14	3.4 - 58	> 0.0010
Manual count & outline, MART1-adjusted hot spot, ≤ 7.7/mm² vs. > 7.7/mm²	6.1	2.7 - 14	> 0.0010
Manual count & outline, MART1-adjusted global, ≤ 3.3/mm² vs. > 3.3/mm²	4.3	2.1 - 9.0	> 0.0010
Automated count & manual outline, hot spot, 0 vs. ≥ 1.0	3.4	1.7 - 6.8	> 0.0010
Automated count & outline, hot spot, ≤ 2.0 vs. > 2.0	3.8	2.0 - 7.1	> 0.0010
Automated count & outline, MART1-adjusted hot spot, ≤ 14/mm² vs. > 14/mm²	3.3	1.6 - 6.5	0.0010
Automated count & manual outline, MART1-adjusted global, ≤ 4.0/mm² vs. > 4.0/mm²	2.5	1.3 - 4.9	0.0060

Abbreviations: PHH3 phosphohistone H3, HR hazard ratio, CI confidence interval