Fig. 3.

Targeting of the Wnt/β-catenin signaling pathway by Tat altered miRNAs. Ingenuity pathway analysis software was used to predict the downstream targets of the 18 tight Tat binders and to visualize the Wnt/β-catenin pathway. Proteins with symbols filled in gray are targets of Tat bound miRNAs. miRNAs confirmed to be down-regulated at the whole cell level are shown on the right. The dashed lines depict the targets of these eight miRNAs