Table 1.
Patient | Plasma HIV RNA history, copies/mLa | Plasma HIV RNA at enrollment, copies/mL | CD4+ T cell count,bcells/mm3 |
CD4+ T cell count at enrollment, cells/mm3 | CD4+ T cell count at enrollment, % | ART regimen at enrollment, (months on ART regimen] | ART regimen at change | Sex; age, years | |
---|---|---|---|---|---|---|---|---|---|
Highest count | Nadir count | ||||||||
1 | BLD | <50 | 1141 | 311 | 311 | 20 | ddl, TDF, 3TC (18) | TDF, 3TC, ABC, ATZ, RTV | F; 51 |
2 | BLD | <50 | 746 | 272 | 272 | 24 | ddl, TDF, 3TC (24) | EFV, AZT, 3TC | M; 66 |
3 | BLD | <50 | 692 | 174 | 219 | 19 | ddl, ABC, NVP (29) | ddl, ABC, NVP, ATZ | F; 39 |
4 | BLD | <50 | 360 | 182 | 193 | 16 | ddl, TDF, EFV, d4T (7) | ddl, TDF, EFV | M; 34 |
All patients, median | ... | ... | 719 | 227 | 246 | ... | ... | ... | ... |
NOTE. ABC, abacavir; ART, combination antiretroviral therapy; ATZ, atazanavir; AZT, zidovudine; BLD, below the limit of detection for the assay; d4T, stavudine; ddl, didanosine; EFV, efavirenz; HIV, human immunodeficiency virus; NVP, nevirapine; RTV, ritonavir, TDF, tenofovir; 3TC, lamivudine.
These assays were performed in the 18-24 months before enrollment and represent values of <50 or <400 copies/mL, depending on the assay.
The highest and nadir CD4+ T cell counts were obtained during an 18-24-month period before enrollment.