Table 2.
Patient | Ultrasensitive plasma HIV RNA, copies/mL | Peripheral caRNA level, copies/106 PBMCs | Lymph node caRNA level, copies/106 LNMCs | Peripheral pvDNA level, copies/106 CD8-depleted PBMCs | Lymph node pvDNA level, copies/106 LNMCs | Resistance demonstrated by OLA | Resistance demonstrated by TRUGENE |
---|---|---|---|---|---|---|---|
1 | 5 | <50 | ND | 48 | NA | None | ND |
2 | <1 | <50 | <50 | 6 | NA | Low peripheral levels of M184V | ND |
3 | 1 | <50 | <50 | 81 | 800 | None | None |
4 | <1 | <50 | <50 | 292 | 60 | None | ND |
NOTE. caRNA, cell-associated human immunodeficiency virus (HIV) RNA; LNMCs, lymph node mononuclear cells; NA, not amplifiable with polymerase chain reaction, given several attempts; ND, not determined, insufficient sample to assay; OLA, oligonucleotide ligation assay; PBMCs, peripheral blood mononuclear cells; pvDNA, proviral HIV DNA; TRUGENE, genotypic resistance assay (Visible Genetics).