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. Author manuscript; available in PMC: 2016 Apr 9.
Published in final edited form as: Hepatol Int. 2015 Aug 29;9(4):527–533. doi: 10.1007/s12072-015-9656-7

Fig. 1.

Fig. 1

Schematic representation of the activation of TGR5 and FXR by bile acids. TGR5 is a plasma membrane G protein coupled receptor and FXR is a nuclear receptor that is activated by bile acids. The receptors are activated by both primary (CA and CDCA) and secondary bile acids (LCA and DCA). LCA is a potent activator of TGR5 while CDCA for FXR