Table 1.
Biliary Atresia Outcomes by 2 Years of Age
| Outcome Events | Number (%) of Patients with Event | Odds Ratio and 95 % CI for TB ≥ 2 vs TB < 2 mg/dL | P-value | ||
|---|---|---|---|---|---|
| All BA (n=137) | TB Status by 3 months after HPE | ||||
| TB < 2 mg/dL (n = 68) | TB ≥ 2 mg/dL (n = 69) | ||||
| Weight z-Score < −2.5 | 28 (20.4%) | 8 (11.8%) | 20 (29.0%) | 3.1 (1.2, 7.5) | 0.015 |
| Height z-Score < −2.5 | 26 (18.9%) | 10 (14.7%) | 16 (23.2%) | 1.8 (0.7, 4.2) | 0.21 |
| Midarm Circumference z-score < −2.5 | 51 (37.2%) | 24 (35.3%) | 27 (39.1%) | 1.2 (0.6, 2.4) | 0.64 |
| Hypoalbuminemia (Albumin < 3.0 gr/dL) | 46 (33.6%) | 9 (13.2%) | 37 (53.6%) | 7.6 (3.2, 17.7) | <0.0001 |
| Coagulopathy (INR >1.5) | 26 (19.0%) | 3 (4.4%) | 23 (33.3%) | 10.8 (3.1, 38.2) | 0.0002 |
| Hyponatremia (Na < 130 mEq/L) | 5 (3.7%) | 1 (1.5%) | 4 (5.8%) | 4.1(0.4, 37.9) | 0.21 |
| Thrombocytopenia (Platelets < 150,000/μL) | 65 (47.5%) | 32 (47.1) | 33 (47.8) | 1.03 (0.5, 2.0) | 0.93** |
| Splenomegaly | 86 (62.8%) | 48 (70.6) | 38 (55.1) | 0.5 (0.3, 1.03) | 0.062 |
| Ascites | 52 (38.0%) | 12 (17.7%) | 40 (58.0%) | 6.4 (2.9, 14.1) | <0.0001 |
| Variceal hemorrhage | 9 (6.6%) | 5 (7.4%) | 4 (5.8%) | 0.8 (0.2, 3.0) | 0.71 |
| Liver Transplant | 57 (41.6%) | 10 (14.7%) | 47 (68.1%) | 12.4 (5.3, 28.7) | <0.0001 |
| Death | 9 (6.6%) | 2 (2.9%) | 7 (10.1%) | 3.7 (0.7, 18.6) | 0.11 |
| Death or Liver Transplant | 66 (48.2%) | 12 (17.7%) | 54 (78.3%) | 16.8 (7.2, 39.2) | <0.0001 |
*
Bold indicates P value < 0.05
**
Note by Kaplan-Meier analysis, thrombocytopenia was more common for TB>2 (Figure 1)