Table 1.

Prevalence of LRP4 antibodies in studies of seronegative MG [68–71]

Investigators	Experimental method	Prevalence in SNMG	Definition of SNMG	Double positives
Higuchi et al. [68]	Luciferase-reporter immunoprecipitation	3 % (9/300)	AChR −ve	3 of the 9 LRP4 +ve samples were also MuSK +ve
Pevzner et al. [69]	CBA	54 % (7/13)	AChR and MuSK −ve	A control MuSK sample was also LRP4 +ve
Zhang et al. [70]	ELISA	9.2 % (11/120)	AChR and MuSK −ve	1 of 36 MuSK samples tested was also LRP4 +ve
Zisimopoulou et al. [71]	CBA	18.7 % (119/635)	AChR and MuSK −ve	8/107 AChR +ve and 10/67 MuSK +ve samples also LRP4 +ve